Assay Detail
Functional
CHEMBL952866
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Antitrypanosomal activity against intracellular Trypanosoma cruzi amastigotes in rat L6 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Cell Type | L6 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Kinetic characterization of squalene synthase from Trypanosoma cruzi: selective inhibition by quinuclidine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.12 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL258717 | — | — | 1 | 8.10 |
| CHEMBL258503 | — | — | 1 | 7.96 |
| CHEMBL261776 | — | — | 1 | 5.51 |
| CHEMBL405590 | — | — | 1 | 5.33 |
| CHEMBL406774 | — | — | 1 | 5.02 |
| CHEMBL259665 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL258717 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL258503 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL261776 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL405590 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL406774 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL259665 | — | IC50 | = | 16000.0 | nM | 4.80 |