Assay Detail
ADMET
CHEMBL953406
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Inhibition of human CYP3A4
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of orally active pyrrolopyridine- and aminopyridine-based Met kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.60 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL500157 | — | — | 1 | 6.16 |
| CHEMBL502531 | — | — | 1 | 6.10 |
| CHEMBL526929 | — | — | 1 | 5.75 |
| CHEMBL525049 | — | — | 1 | 5.57 |
| CHEMBL500422 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL500157 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL502531 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL526929 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL525049 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL500422 | — | IC50 | = | 37000.0 | nM | 4.43 |