Assay Detail
Binding
CHEMBL954162
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 5.96 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 7.60 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 7.30 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 6.50 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.45 |
| CHEMBL1112 | ARIPIPRAZOLE | 4.0 | 1 | 5.71 |
| CHEMBL496739 | — | — | 1 | 5.48 |
| CHEMBL497574 | — | — | 1 | 5.37 |
| CHEMBL496531 | — | — | 1 | 5.36 |
| CHEMBL462508 | — | — | 1 | 5.34 |
| CHEMBL461236 | — | — | 1 | 5.26 |
| CHEMBL495572 | — | — | 1 | 5.15 |
| CHEMBL522044 | — | — | 1 | - |
| CHEMBL495573 | — | — | 1 | - |
| CHEMBL497573 | — | — | 1 | - |
| CHEMBL497604 | — | — | 1 | - |
| CHEMBL461023 | — | — | 1 | - |
| CHEMBL517730 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL715 | OLANZAPINE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL85 | RISPERIDONE | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 318.0 | nM | 6.50 |
| CHEMBL42 | CLOZAPINE | Ki | = | 353.0 | nM | 6.45 |
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 1960.0 | nM | 5.71 |
| CHEMBL496739 | — | Ki | = | 3290.0 | nM | 5.48 |
| CHEMBL497574 | — | Ki | = | 4315.0 | nM | 5.37 |
| CHEMBL496531 | — | Ki | = | 4370.0 | nM | 5.36 |
| CHEMBL462508 | — | Ki | = | 4600.0 | nM | 5.34 |
| CHEMBL461236 | — | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL495572 | — | Ki | = | 7124.0 | nM | 5.15 |
| CHEMBL522044 | — | Ki | - | — | - | |
| CHEMBL495573 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL497573 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL497604 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL461023 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL517730 | — | Ki | > | 10000.0 | nM | - |