Assay Detail
Functional
CHEMBL954231
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at rat 5HT2A receptor expressed in mouse NIH3T3 cells assessed as stimulation of inositol phosphate accumulation
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | NIH3T3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
'Hybrid' benzofuran-benzopyran congeners as rigid analogs of hallucinogenic phenethylamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.37 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL482703 | — | — | 1 | 8.03 |
| CHEMBL520449 | — | — | 1 | 7.89 |
| CHEMBL101008 | — | — | 1 | 7.89 |
| CHEMBL519145 | — | — | 1 | 7.72 |
| CHEMBL6607 | BROLAMFETAMINE | 2.0 | 1 | 7.66 |
| CHEMBL520133 | — | — | 1 | 7.11 |
| CHEMBL482704 | — | — | 1 | 6.84 |
| CHEMBL482675 | — | — | 1 | 6.62 |
| CHEMBL482702 | — | — | 1 | 6.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL482703 | — | EC50 | = | 9.4 | nM | 8.03 |
| CHEMBL520449 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL101008 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL519145 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL6607 | BROLAMFETAMINE | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL520133 | — | EC50 | = | 78.0 | nM | 7.11 |
| CHEMBL482704 | — | EC50 | = | 146.0 | nM | 6.84 |
| CHEMBL482675 | — | EC50 | = | 241.0 | nM | 6.62 |
| CHEMBL482702 | — | EC50 | = | 258.0 | nM | 6.59 |