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Assay Detail

CHEMBL954305

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of caspase-like activity of 20S proteasome beta 1 subunit by fluorimeter
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

New cyclic peptide proteasome inhibitors.
Baldisserotto A, Marastoni M, Gavioli R, Tomatis R.
Bioorg Med Chem Lett (2009) 19 : 1966 -1969
PubMed 19250821 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 6.56 7.19

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL500747 1 7.19
CHEMBL457409 1 6.92
CHEMBL462403 1 6.76
CHEMBL445424 1 6.69
CHEMBL207990 EPOXOMYCIN 1 5.25
CHEMBL64925 MG-132 1 -
CHEMBL447324 1 -
CHEMBL502048 1 -
CHEMBL458737 1 -
CHEMBL448436 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL500747 IC50 = 65.0 nM 7.19
CHEMBL457409 IC50 = 121.0 nM 6.92
CHEMBL462403 IC50 = 172.0 nM 6.76
CHEMBL445424 IC50 = 205.0 nM 6.69
CHEMBL207990 EPOXOMYCIN IC50 = 5640.0 nM 5.25
CHEMBL64925 MG-132 IC50 > 10000.0 nM -
CHEMBL447324 IC50 > 10000.0 nM -
CHEMBL502048 IC50 > 10000.0 nM -
CHEMBL458737 IC50 > 10000.0 nM -
CHEMBL448436 IC50 > 10000.0 nM -