Assay Detail
Binding
CHEMBL955666
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Displacement of [3H]DAMGO from mu opioid receptor in human SHSY5Y cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and in vitro evaluation of a library of modified endomorphin 1 peptides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 8.08 | 10.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL412923 | — | — | 1 | 10.23 |
| CHEMBL509528 | — | — | 1 | 10.09 |
| CHEMBL316446 | ENDOMORPHIN-1 | — | 1 | 8.96 |
| CHEMBL471806 | — | — | 1 | 8.67 |
| CHEMBL510939 | — | — | 1 | 8.54 |
| CHEMBL500704 | — | — | 1 | 8.52 |
| CHEMBL505960 | — | — | 1 | 7.81 |
| CHEMBL499141 | — | — | 1 | 6.94 |
| CHEMBL503367 | — | — | 1 | 6.92 |
| CHEMBL446814 | — | — | 1 | 6.83 |
| CHEMBL451830 | — | — | 1 | 6.82 |
| CHEMBL526349 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL412923 | — | Ki | = | 0.059 | nM | 10.23 |
| CHEMBL509528 | — | Ki | = | 0.081 | nM | 10.09 |
| CHEMBL316446 | ENDOMORPHIN-1 | Ki | = | 1.11 | nM | 8.96 |
| CHEMBL471806 | — | Ki | = | 2.15 | nM | 8.67 |
| CHEMBL510939 | — | Ki | = | 2.92 | nM | 8.54 |
| CHEMBL500704 | — | Ki | = | 3.02 | nM | 8.52 |
| CHEMBL505960 | — | Ki | = | 15.4 | nM | 7.81 |
| CHEMBL499141 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL503367 | — | Ki | = | 121.0 | nM | 6.92 |
| CHEMBL446814 | — | Ki | = | 148.0 | nM | 6.83 |
| CHEMBL451830 | — | Ki | = | 151.0 | nM | 6.82 |
| CHEMBL526349 | — | Ki | = | 266.0 | nM | 6.58 |