Assay Detail
Binding
CHEMBL955770
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Inhibition of ovine COX1 by enzyme immuno assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of celecoxib analogs that possess a N-hydroxypyrid-2(1H)one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.36 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25 | ASPIRIN | 4.0 | 1 | 6.46 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 5.11 |
| CHEMBL462224 | — | — | 1 | 4.99 |
| CHEMBL452605 | — | — | 1 | 4.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25 | ASPIRIN | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL118 | CELECOXIB | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL462224 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL452605 | — | IC50 | = | 13200.0 | nM | 4.88 |