Assay Detail
Binding
CHEMBL956718
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]ketanserin from 5HT2A receptor in rat cortical membrane
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The influence of an ethylene spacer on the 5-HT(1A) and 5-HT(2A) receptor affinity of arylpiperazine derivatives of amides with N-acylated amino acids and 3-differently substituted pyrrolidine-2,5-diones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 6.15 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 8.22 |
| CHEMBL408589 | — | — | 1 | 8.19 |
| CHEMBL514077 | — | — | 1 | 7.82 |
| CHEMBL209007 | — | — | 1 | 7.33 |
| CHEMBL515933 | — | — | 1 | 7.12 |
| CHEMBL477034 | — | — | 1 | 7.04 |
| CHEMBL477871 | — | — | 1 | 6.89 |
| CHEMBL477945 | — | — | 1 | 6.86 |
| CHEMBL478068 | — | — | 1 | 6.79 |
| CHEMBL208905 | — | — | 1 | 6.76 |
| CHEMBL378298 | — | — | 1 | 6.74 |
| CHEMBL60322 | — | — | 1 | 6.59 |
| CHEMBL478265 | — | — | 1 | 6.45 |
| CHEMBL377153 | — | — | 1 | 6.30 |
| CHEMBL476221 | — | — | 1 | 6.10 |
| CHEMBL514202 | — | — | 1 | 6.06 |
| CHEMBL208735 | — | — | 1 | 6.00 |
| CHEMBL477427 | — | — | 1 | 5.88 |
| CHEMBL477266 | — | — | 1 | 5.85 |
| CHEMBL476260 | — | — | 1 | 5.76 |
| CHEMBL477027 | — | — | 1 | 5.72 |
| CHEMBL476054 | — | — | 1 | 5.67 |
| CHEMBL514070 | — | — | 1 | 5.63 |
| CHEMBL476169 | — | — | 1 | 5.50 |
| CHEMBL515930 | — | — | 1 | 5.49 |
| CHEMBL476010 | — | — | 1 | 5.32 |
| CHEMBL476261 | — | — | 1 | 5.25 |
| CHEMBL476062 | — | — | 1 | 5.13 |
| CHEMBL477428 | — | — | 1 | 5.07 |
| CHEMBL477414 | — | — | 1 | 5.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | Ki | = | 6.05 | nM | 8.22 |
| CHEMBL408589 | — | Ki | = | 6.51 | nM | 8.19 |
| CHEMBL514077 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL209007 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL515933 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL477034 | — | Ki | = | 92.0 | nM | 7.04 |
| CHEMBL477871 | — | Ki | = | 128.0 | nM | 6.89 |
| CHEMBL477945 | — | Ki | = | 137.0 | nM | 6.86 |
| CHEMBL478068 | — | Ki | = | 163.0 | nM | 6.79 |
| CHEMBL208905 | — | Ki | = | 173.0 | nM | 6.76 |
| CHEMBL378298 | — | Ki | = | 183.0 | nM | 6.74 |
| CHEMBL60322 | — | Ki | = | 254.0 | nM | 6.59 |
| CHEMBL478265 | — | Ki | = | 357.0 | nM | 6.45 |
| CHEMBL377153 | — | Ki | = | 503.0 | nM | 6.30 |
| CHEMBL476221 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL514202 | — | Ki | = | 868.0 | nM | 6.06 |
| CHEMBL208735 | — | Ki | = | 990.0 | nM | 6.00 |
| CHEMBL477427 | — | Ki | = | 1302.0 | nM | 5.88 |
| CHEMBL477266 | — | Ki | = | 1411.0 | nM | 5.85 |
| CHEMBL476260 | — | Ki | = | 1742.0 | nM | 5.76 |
| CHEMBL477027 | — | Ki | = | 1917.0 | nM | 5.72 |
| CHEMBL476054 | — | Ki | = | 2120.0 | nM | 5.67 |
| CHEMBL514070 | — | Ki | = | 2326.0 | nM | 5.63 |
| CHEMBL476169 | — | Ki | = | 3140.0 | nM | 5.50 |
| CHEMBL515930 | — | Ki | = | 3258.0 | nM | 5.49 |
| CHEMBL476010 | — | Ki | = | 4799.0 | nM | 5.32 |
| CHEMBL476261 | — | Ki | = | 5678.0 | nM | 5.25 |
| CHEMBL476062 | — | Ki | = | 7343.0 | nM | 5.13 |
| CHEMBL477428 | — | Ki | = | 8600.0 | nM | 5.07 |
| CHEMBL477414 | — | Ki | = | 8706.0 | nM | 5.06 |
| CHEMBL478269 | — | Ki | = | 12417.0 | nM | 4.91 |
| CHEMBL476217 | — | Ki | = | 14936.0 | nM | 4.83 |
| CHEMBL476053 | — | Ki | = | 17570.0 | nM | 4.75 |