Assay Detail
ADMET
CHEMBL957339
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Inhibition of CYP2D6 in human liver microsomes assessed as dextromethorphan O-demethylase activity
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
4-benzyl-1H-imidazoles with oxazoline termini as histamine H3 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.13 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494982 | — | — | 1 | 6.54 |
| CHEMBL449840 | — | — | 1 | 6.31 |
| CHEMBL455475 | — | — | 1 | 6.26 |
| CHEMBL451399 | — | — | 1 | 6.19 |
| CHEMBL493014 | — | — | 1 | 5.75 |
| CHEMBL489493 | — | — | 1 | 5.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494982 | — | IC50 | = | 292.0 | nM | 6.54 |
| CHEMBL449840 | — | IC50 | = | 488.0 | nM | 6.31 |
| CHEMBL455475 | — | IC50 | = | 543.0 | nM | 6.26 |
| CHEMBL451399 | — | IC50 | = | 644.0 | nM | 6.19 |
| CHEMBL493014 | — | IC50 | = | 1785.0 | nM | 5.75 |
| CHEMBL489493 | — | IC50 | = | 1926.0 | nM | 5.71 |