Assay Detail
Binding
CHEMBL958094
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Displacement of [3H]paroxetine from serotonin transporter
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and receptor binding properties of 2beta-alkynyl and 2beta-(1,2,3-triazol)substituted 3beta-(substituted phenyl)tropane derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.06 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494626 | — | — | 1 | 8.15 |
| CHEMBL449047 | — | — | 1 | 7.75 |
| CHEMBL496913 | — | — | 1 | 7.72 |
| CHEMBL495464 | — | — | 1 | 7.41 |
| CHEMBL451071 | — | — | 1 | 7.27 |
| CHEMBL494624 | — | — | 1 | 7.12 |
| CHEMBL494814 | — | — | 1 | 7.09 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 7.02 |
| CHEMBL496911 | — | — | 1 | 6.86 |
| CHEMBL523916 | — | — | 1 | 6.79 |
| CHEMBL494786 | — | — | 1 | 6.74 |
| CHEMBL524188 | — | — | 1 | 6.60 |
| CHEMBL522699 | — | — | 1 | 6.21 |
| CHEMBL494807 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494626 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL449047 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL496913 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL495464 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL451071 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL494624 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL494814 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL370805 | COCAINE | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL496911 | — | Ki | = | 138.0 | nM | 6.86 |
| CHEMBL523916 | — | Ki | = | 161.0 | nM | 6.79 |
| CHEMBL494786 | — | Ki | = | 182.0 | nM | 6.74 |
| CHEMBL524188 | — | Ki | = | 252.0 | nM | 6.60 |
| CHEMBL522699 | — | Ki | = | 620.0 | nM | 6.21 |
| CHEMBL494807 | — | Ki | = | 730.0 | nM | 6.14 |