Assay Detail
Binding
CHEMBL958367
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Displacement of [3H]citalopram from SERT
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Selective 5-hydroxytryptamine 2C receptor agonists derived from the lead compound tranylcypromine: identification of drugs with antidepressant-like action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.56 | 5.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL451232 | — | — | 1 | 5.98 |
| CHEMBL360328 | LORCASERIN | 4.0 | 1 | 5.58 |
| CHEMBL493130 | — | — | 1 | 5.57 |
| CHEMBL492916 | — | — | 1 | 5.57 |
| CHEMBL467736 | — | — | 1 | 5.42 |
| CHEMBL445747 | — | — | 1 | 5.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL451232 | — | Ki | = | 1042.0 | nM | 5.98 |
| CHEMBL360328 | LORCASERIN | Ki | = | 2606.0 | nM | 5.58 |
| CHEMBL493130 | — | Ki | = | 2710.0 | nM | 5.57 |
| CHEMBL492916 | — | Ki | = | 2716.0 | nM | 5.57 |
| CHEMBL467736 | — | Ki | = | 3824.0 | nM | 5.42 |
| CHEMBL445747 | — | Ki | = | 5441.0 | nM | 5.26 |