Assay Detail
Binding
CHEMBL959281
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant full length CA5A by stopped flow CO2 hydration assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Carbonic anhydrase 5A, mitochondrial (CHEMBL4789) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.02 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.20 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.19 |
| CHEMBL455271 | — | — | 1 | 7.14 |
| CHEMBL262628 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL455271 | — | Ki | = | 72.7 | nM | 7.14 |
| CHEMBL262628 | — | Ki | = | 1100.0 | nM | 5.96 |