Assay Detail
Binding
CHEMBL961254
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Fms-mediated CSF1-stimulated mouse BMDM proliferation by bromodeoxyuridine incorporation assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Macrophage colony-stimulating factor 1 receptor (CHEMBL5570) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Pyrido[2,3-d]pyrimidin-5-ones: a novel class of antiinflammatory macrophage colony-stimulating factor-1 receptor inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 8.23 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL492809 | — | — | 1 | 9.22 |
| CHEMBL489684 | — | — | 1 | 9.22 |
| CHEMBL448339 | — | — | 1 | 9.15 |
| CHEMBL522834 | — | — | 1 | 9.05 |
| CHEMBL521580 | — | — | 1 | 9.00 |
| CHEMBL451931 | — | — | 1 | 9.00 |
| CHEMBL489298 | — | — | 1 | 8.96 |
| CHEMBL505830 | — | — | 1 | 8.89 |
| CHEMBL489881 | — | — | 1 | 8.70 |
| CHEMBL445519 | — | — | 1 | 8.70 |
| CHEMBL448117 | — | — | 1 | 8.68 |
| CHEMBL508935 | — | — | 1 | 8.62 |
| CHEMBL489883 | — | — | 1 | 8.60 |
| CHEMBL451575 | — | — | 1 | 8.48 |
| CHEMBL509044 | — | — | 1 | 8.27 |
| CHEMBL403776 | — | — | 1 | 8.05 |
| CHEMBL490080 | — | — | 1 | 7.94 |
| CHEMBL455591 | — | — | 1 | 7.92 |
| CHEMBL414001 | — | — | 1 | 7.80 |
| CHEMBL452965 | — | — | 1 | 7.64 |
| CHEMBL511484 | — | — | 1 | 7.58 |
| CHEMBL507619 | — | — | 1 | 7.35 |
| CHEMBL472403 | — | — | 1 | 7.26 |
| CHEMBL451918 | — | — | 1 | 7.25 |
| CHEMBL491078 | — | — | 1 | 7.08 |
| CHEMBL444454 | — | — | 1 | 7.00 |
| CHEMBL450914 | — | — | 1 | 6.89 |
| CHEMBL523802 | — | — | 1 | - |
| CHEMBL514153 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL492809 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL489684 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL448339 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL522834 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL521580 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL451931 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL489298 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL505830 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL489881 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL445519 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL448117 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL508935 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL489883 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL451575 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL509044 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL403776 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL490080 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL455591 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL414001 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL452965 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL511484 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL507619 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL472403 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL451918 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL491078 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL444454 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL450914 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL523802 | — | IC50 | > | 300.0 | nM | - |
| CHEMBL514153 | — | IC50 | > | 300.0 | nM | - |