Assay Detail
Binding
CHEMBL961607
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FAAH at pH 9
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Correlation of inhibitor effects on enzyme activity and thermal stability for the integral membrane protein fatty acid amide hydrolase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.12 | 9.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL178398 | — | — | 1 | 9.54 |
| CHEMBL227046 | — | — | 1 | 9.12 |
| CHEMBL220614 | — | — | 1 | 9.00 |
| CHEMBL177577 | — | — | 1 | 8.33 |
| CHEMBL219880 | — | — | 1 | 8.10 |
| CHEMBL461163 | — | — | 1 | 7.85 |
| CHEMBL219942 | — | — | 1 | 7.70 |
| CHEMBL260747 | — | — | 1 | 7.66 |
| CHEMBL410933 | — | — | 1 | 7.55 |
| CHEMBL270284 | — | — | 1 | 7.40 |
| CHEMBL173992 | — | — | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL178398 | — | Ki | = | 0.29 | nM | 9.54 |
| CHEMBL227046 | — | Ki | = | 0.75 | nM | 9.12 |
| CHEMBL220614 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL177577 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL219880 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL461163 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL219942 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL260747 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL410933 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL270284 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL173992 | — | Ki | = | 80.0 | nM | 7.10 |