Compound Detail
CHEMBL220614
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Basic Information
| ChEMBL ID | CHEMBL220614 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HSSWVCXBDHBFNI-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
377.4
MW (Da)
4.21
ALogP
5
HBA
1
HBD
99.1
PSA (Ų)
0.42
QED
0
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 9.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 CHEMBL2243 | Ki | 9.0 | 9.0 | 1.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 | Ki | = | 1.0 | nM | 9.0 | Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamid... | 17279740 |
| Fatty-acid amide hydrolase 1 | Ki | = | 1.0 | nM | 9.0 | Inhibition of FAAH at pH 9 | 18644727 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18644727 | 10.1016/j.bmcl.2008.06.086 | Fatty-acid amide hydrolase 1 | 2 |
| 17279740 | 10.1021/jm0611509 | Fatty-acid amide hydrolase 1 | 1 |
Data from ChEMBL 36 via Core Engine