Assay Detail
Functional
CHEMBL961999
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against trypomastigotes of Trypanosoma cruzi Tulahuen C2C4 containing lacZ gene in rat L6 cells after 4 days by chlorophenol red-beta-D-galactopyranoside/Nonidet assay
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Cell Type | L6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Quinuclidine derivatives as potential antiparasitics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 50 | 4.77 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL506578 | — | — | 1 | 5.75 |
| CHEMBL517057 | — | — | 1 | 5.55 |
| CHEMBL478724 | — | — | 1 | 5.51 |
| CHEMBL453439 | — | — | 1 | 5.51 |
| CHEMBL477326 | — | — | 1 | 5.47 |
| CHEMBL99679 | — | — | 1 | 5.33 |
| CHEMBL517050 | — | — | 1 | 5.33 |
| CHEMBL478533 | — | — | 1 | 5.28 |
| CHEMBL443678 | — | — | 1 | 5.25 |
| CHEMBL478532 | — | — | 1 | 5.25 |
| CHEMBL479211 | — | — | 1 | 5.25 |
| CHEMBL517819 | — | — | 1 | 5.24 |
| CHEMBL391926 | — | — | 1 | 5.09 |
| CHEMBL478339 | — | — | 1 | 5.02 |
| CHEMBL478981 | — | — | 1 | 4.99 |
| CHEMBL515183 | — | — | 1 | 4.87 |
| CHEMBL259665 | — | — | 1 | 4.80 |
| CHEMBL518134 | — | — | 1 | 4.79 |
| CHEMBL477492 | — | — | 1 | 4.73 |
| CHEMBL478112 | — | — | 1 | 4.72 |
| CHEMBL505301 | — | — | 1 | 4.72 |
| CHEMBL478723 | — | — | 1 | 4.71 |
| CHEMBL479212 | — | — | 1 | 4.67 |
| CHEMBL479189 | — | — | 1 | 4.64 |
| CHEMBL477079 | — | — | 1 | 4.64 |
| CHEMBL477305 | — | — | 1 | 4.59 |
| CHEMBL506873 | — | — | 1 | 4.59 |
| CHEMBL478348 | — | — | 1 | 4.59 |
| CHEMBL478349 | — | — | 1 | 4.58 |
| CHEMBL478912 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL506578 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL517057 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL478724 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL453439 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL477326 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL99679 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL517050 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL478533 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL443678 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL478532 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL479211 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL517819 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL391926 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL478339 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL478981 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL515183 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL259665 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL518134 | — | IC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL477492 | — | IC50 | = | 18800.0 | nM | 4.73 |
| CHEMBL478112 | — | IC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL505301 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL478723 | — | IC50 | = | 19400.0 | nM | 4.71 |
| CHEMBL479212 | — | IC50 | = | 21200.0 | nM | 4.67 |
| CHEMBL479189 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL477079 | — | IC50 | = | 22900.0 | nM | 4.64 |
| CHEMBL477305 | — | IC50 | = | 25600.0 | nM | 4.59 |
| CHEMBL478348 | — | IC50 | = | 25600.0 | nM | 4.59 |
| CHEMBL506873 | — | IC50 | = | 25400.0 | nM | 4.59 |
| CHEMBL478349 | — | IC50 | = | 26200.0 | nM | 4.58 |
| CHEMBL478912 | — | IC50 | = | 30200.0 | nM | 4.52 |
| CHEMBL516895 | — | IC50 | = | 34100.0 | nM | 4.47 |
| CHEMBL477322 | — | IC50 | = | 33800.0 | nM | 4.47 |
| CHEMBL478531 | — | IC50 | = | 44900.0 | nM | 4.35 |
| CHEMBL504277 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL477327 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL478340 | — | IC50 | = | 51100.0 | nM | 4.29 |
| CHEMBL109405 | — | IC50 | = | 61300.0 | nM | 4.21 |
| CHEMBL344327 | — | IC50 | = | 64200.0 | nM | 4.19 |
| CHEMBL516436 | — | IC50 | = | 67200.0 | nM | 4.17 |
| CHEMBL518600 | — | IC50 | = | 72600.0 | nM | 4.14 |
| CHEMBL479223 | — | IC50 | = | 90200.0 | nM | 4.04 |
| CHEMBL442578 | — | IC50 | = | 90400.0 | nM | 4.04 |
| CHEMBL478350 | — | IC50 | = | 97000.0 | nM | 4.01 |
| CHEMBL478359 | — | IC50 | > | 132000.0 | nM | - |
| CHEMBL478358 | — | IC50 | > | 151000.0 | nM | - |
| CHEMBL2094001 | — | IC50 | > | 111000.0 | nM | - |
| CHEMBL478913 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL445817 | — | IC50 | > | 131000.0 | nM | - |
| CHEMBL478530 | — | IC50 | > | 114000.0 | nM | - |
| CHEMBL478347 | — | IC50 | > | 117000.0 | nM | - |