Assay Detail
Functional
CHEMBL963034
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Cytotoxicity against human KBV1 cells by MTT method
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB-V1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
11-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridine derivatives as novel topoisomerase I-targeting agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.46 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70790 | — | — | 1 | 8.30 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.60 |
| CHEMBL509143 | — | — | 1 | 7.22 |
| CHEMBL453900 | — | — | 1 | 6.80 |
| CHEMBL454886 | — | — | 1 | 6.60 |
| CHEMBL488454 | — | — | 1 | 6.52 |
| CHEMBL509379 | — | — | 1 | 6.48 |
| CHEMBL454887 | — | — | 1 | 6.44 |
| CHEMBL452855 | — | — | 1 | 6.40 |
| CHEMBL488453 | — | — | 1 | 6.40 |
| CHEMBL452854 | — | — | 1 | 6.40 |
| CHEMBL455714 | — | — | 1 | 6.38 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 6.36 |
| CHEMBL507586 | — | — | 1 | 6.35 |
| CHEMBL455688 | — | — | 1 | 6.30 |
| CHEMBL455715 | — | — | 1 | 5.85 |
| CHEMBL510447 | — | — | 1 | 5.40 |
| CHEMBL481 | IRINOTECAN | 4.0 | 1 | 4.40 |
| CHEMBL520409 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70790 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL509143 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL453900 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL454886 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL488454 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL509379 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL454887 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL452855 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL488453 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL452854 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL455714 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL507586 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL455688 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL455715 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL510447 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL481 | IRINOTECAN | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL520409 | — | IC50 | > | 10000.0 | nM | - |