Assay Detail
Functional
CHEMBL963035
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Cytotoxicity against human KBH5.0 cells by MTT method
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KBH5.0 cell |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
11-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridine derivatives as novel topoisomerase I-targeting agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.60 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70790 | — | — | 1 | 8.22 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.58 |
| CHEMBL509143 | — | — | 1 | 7.40 |
| CHEMBL509379 | — | — | 1 | 7.16 |
| CHEMBL455688 | — | — | 1 | 6.96 |
| CHEMBL452854 | — | — | 1 | 6.89 |
| CHEMBL455715 | — | — | 1 | 6.70 |
| CHEMBL453900 | — | — | 1 | 6.68 |
| CHEMBL488454 | — | — | 1 | 6.54 |
| CHEMBL454886 | — | — | 1 | 6.54 |
| CHEMBL454887 | — | — | 1 | 6.50 |
| CHEMBL488453 | — | — | 1 | 6.40 |
| CHEMBL507586 | — | — | 1 | 6.38 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 6.36 |
| CHEMBL455714 | — | — | 1 | 6.32 |
| CHEMBL452855 | — | — | 1 | 5.57 |
| CHEMBL510447 | — | — | 1 | 5.44 |
| CHEMBL481 | IRINOTECAN | 4.0 | 1 | 5.13 |
| CHEMBL520409 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70790 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL509143 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL509379 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL455688 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL452854 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL455715 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL453900 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL488454 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL454886 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL454887 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL488453 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL507586 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL455714 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL452855 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL510447 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL481 | IRINOTECAN | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL520409 | — | IC50 | > | 10000.0 | nM | - |