Assay Detail
Binding
CHEMBL964113
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SCV helicase assessed as duplex-DNA unwinding by FRET based assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome-related coronavirus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL5118) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome-related coronavirus |
Publication
Aryl diketoacids (ADK) selectively inhibit duplex DNA-unwinding activity of SARS coronavirus NTPase/helicase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.81 | 5.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL492571 | — | — | 1 | 5.27 |
| CHEMBL522710 | — | — | 1 | 4.96 |
| CHEMBL492771 | — | — | 1 | 4.87 |
| CHEMBL492772 | — | — | 1 | 4.54 |
| CHEMBL492768 | — | — | 1 | 4.40 |
| CHEMBL492769 | — | — | 1 | - |
| CHEMBL492770 | — | — | 1 | - |
| CHEMBL499444 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL492571 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL522710 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL492771 | — | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL492772 | — | IC50 | = | 28700.0 | nM | 4.54 |
| CHEMBL492768 | — | IC50 | = | 39900.0 | nM | 4.40 |
| CHEMBL492769 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL492770 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL499444 | — | IC50 | > | 50000.0 | nM | - |