Assay Detail
Binding
CHEMBL964136
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Displacement of [3H]DHT from human cloned androgen receptor expressed in Sf9 cells
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 6.82 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL510145 | — | — | 1 | 7.70 |
| CHEMBL453740 | — | — | 1 | 7.70 |
| CHEMBL462664 | — | — | 1 | 7.64 |
| CHEMBL491493 | — | — | 1 | 7.62 |
| CHEMBL445429 | — | — | 1 | 7.54 |
| CHEMBL453623 | — | — | 1 | 7.46 |
| CHEMBL462022 | — | — | 1 | 7.41 |
| CHEMBL443970 | — | — | 1 | 7.40 |
| CHEMBL490956 | — | — | 1 | 7.37 |
| CHEMBL448454 | — | — | 1 | 7.37 |
| CHEMBL462665 | — | — | 1 | 7.31 |
| CHEMBL462026 | — | — | 1 | 7.25 |
| CHEMBL490957 | — | — | 1 | 7.24 |
| CHEMBL453624 | — | — | 1 | 7.20 |
| CHEMBL490955 | — | — | 1 | 7.19 |
| CHEMBL455566 | — | — | 1 | 7.08 |
| CHEMBL449867 | — | — | 1 | 6.94 |
| CHEMBL504110 | — | — | 1 | 6.77 |
| CHEMBL507671 | — | — | 1 | 6.74 |
| CHEMBL449371 | — | — | 1 | 6.71 |
| CHEMBL501649 | — | — | 1 | 6.70 |
| CHEMBL462025 | — | — | 1 | 6.65 |
| CHEMBL448978 | — | — | 1 | 6.50 |
| CHEMBL447604 | — | — | 1 | 6.45 |
| CHEMBL462027 | — | — | 1 | 6.39 |
| CHEMBL453244 | — | — | 1 | 6.36 |
| CHEMBL503687 | — | — | 1 | 6.29 |
| CHEMBL499137 | — | — | 1 | 6.27 |
| CHEMBL462234 | — | — | 1 | 5.87 |
| CHEMBL464764 | — | — | 1 | 5.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL510145 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL453740 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL462664 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL491493 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL445429 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL453623 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL462022 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL443970 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL490956 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL448454 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL462665 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL462026 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL490957 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL453624 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL490955 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL455566 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL449867 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL504110 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL507671 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL449371 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL501649 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL462025 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL448978 | — | IC50 | = | 315.0 | nM | 6.50 |
| CHEMBL447604 | — | IC50 | = | 353.0 | nM | 6.45 |
| CHEMBL462027 | — | IC50 | = | 411.0 | nM | 6.39 |
| CHEMBL453244 | — | IC50 | = | 441.0 | nM | 6.36 |
| CHEMBL503687 | — | IC50 | = | 519.0 | nM | 6.29 |
| CHEMBL499137 | — | IC50 | = | 535.0 | nM | 6.27 |
| CHEMBL462234 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL464764 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL462663 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL464929 | — | IC50 | = | 5210.0 | nM | 5.28 |
| CHEMBL465539 | — | IC50 | = | 5330.0 | nM | 5.27 |
| CHEMBL491492 | — | IC50 | > | 10000.0 | nM | - |