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Compound Detail

CHEMBL490956

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Cc1ccccc1Sc1ccc(C#N)cc1Cl

Basic Information

ChEMBL ID CHEMBL490956
Phase Preclinical
Structure Type MOL
InChI Key XNDBEERQWNGTKH-UHFFFAOYSA-N
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

259.8
MW (Da)
4.67
ALogP
2
HBA
0
HBD
23.8
PSA (Ų)
0.78
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C14H10ClNS
MW 259.76
Aromatic Rings 2
Heavy Atoms 17
NP-Likeness -1.79

Activity Summary

IC50 4 meas. best 7.37

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Androgen receptor
CHEMBL1871
IC50 7.37 7.24 43.0 4

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19201190 10.1016/j.bmcl.2009.01.063 Androgen receptor 2
35786895 10.1021/acs.jmedchem.2c00716 Androgen receptor 2
35786895 10.1021/acs.jmedchem.2c00716 Unchecked 1

Data from ChEMBL 36 via Core Engine