Assay Detail
Functional
CHEMBL964137
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human androgen receptor expressed in human MDA-MB453 cells by luciferase reporter gene assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB453 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.11 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL445429 | — | — | 1 | 8.00 |
| CHEMBL462664 | — | — | 1 | 7.96 |
| CHEMBL448454 | — | — | 1 | 7.52 |
| CHEMBL510145 | — | — | 1 | 7.46 |
| CHEMBL462026 | — | — | 1 | 7.43 |
| CHEMBL490955 | — | — | 1 | 7.34 |
| CHEMBL449867 | — | — | 1 | 7.32 |
| CHEMBL507671 | — | — | 1 | 7.27 |
| CHEMBL504110 | — | — | 1 | 7.26 |
| CHEMBL455566 | — | — | 1 | 7.18 |
| CHEMBL462022 | — | — | 1 | 7.16 |
| CHEMBL490956 | — | — | 1 | 7.11 |
| CHEMBL491493 | — | — | 1 | 7.09 |
| CHEMBL453740 | — | — | 1 | 7.05 |
| CHEMBL462025 | — | — | 1 | 6.91 |
| CHEMBL453623 | — | — | 1 | 6.88 |
| CHEMBL449371 | — | — | 1 | 6.78 |
| CHEMBL490957 | — | — | 1 | 6.71 |
| CHEMBL501649 | — | — | 1 | 6.68 |
| CHEMBL453624 | — | — | 1 | 6.15 |
| CHEMBL462665 | — | — | 1 | 6.08 |
| CHEMBL491492 | — | — | 1 | - |
| CHEMBL447604 | — | — | 1 | - |
| CHEMBL464929 | — | — | 1 | - |
| CHEMBL499137 | — | — | 1 | - |
| CHEMBL464764 | — | — | 1 | - |
| CHEMBL465539 | — | — | 1 | - |
| CHEMBL462027 | — | — | 1 | - |
| CHEMBL462234 | — | — | 1 | - |
| CHEMBL453244 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL445429 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL462664 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL448454 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL510145 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL462026 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL490955 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL449867 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL507671 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL504110 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL455566 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL462022 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL490956 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL491493 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL453740 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL462025 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL453623 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL449371 | — | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL490957 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL501649 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL453624 | — | IC50 | = | 702.0 | nM | 6.15 |
| CHEMBL462665 | — | IC50 | = | 838.0 | nM | 6.08 |
| CHEMBL491492 | — | IC50 | - | — | - | |
| CHEMBL447604 | — | IC50 | - | — | - | |
| CHEMBL464929 | — | IC50 | - | — | - | |
| CHEMBL499137 | — | IC50 | - | — | - | |
| CHEMBL464764 | — | IC50 | - | — | - | |
| CHEMBL465539 | — | IC50 | - | — | - | |
| CHEMBL462027 | — | IC50 | - | — | - | |
| CHEMBL462234 | — | IC50 | - | — | - | |
| CHEMBL453244 | — | IC50 | - | — | - | |
| CHEMBL462663 | — | IC50 | - | — | - | |
| CHEMBL503687 | — | IC50 | - | — | - | |
| CHEMBL448978 | — | IC50 | - | — | - | |
| CHEMBL443970 | — | IC50 | > | 1000.0 | nM | - |