Assay Detail
ADMET
CHEMBL964393
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Inhibition of CYP2C9
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Orally active C-6 heteroaryl- and heterocyclyl-substituted imidazo[1,2-a]pyridine acid pump antagonists (APAs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.24 | 6.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL447822 | — | — | 1 | 6.20 |
| CHEMBL453246 | — | — | 1 | 6.07 |
| CHEMBL526841 | — | — | 1 | 5.96 |
| CHEMBL523752 | — | — | 1 | 5.82 |
| CHEMBL496606 | — | — | 1 | 5.60 |
| CHEMBL521724 | — | — | 1 | 5.60 |
| CHEMBL498026 | — | — | 1 | 5.54 |
| CHEMBL496426 | — | — | 1 | 5.50 |
| CHEMBL496624 | — | — | 1 | 5.50 |
| CHEMBL496806 | — | — | 1 | 5.47 |
| CHEMBL238146 | — | — | 1 | 5.44 |
| CHEMBL498220 | — | — | 1 | 5.43 |
| CHEMBL498114 | — | — | 1 | 5.38 |
| CHEMBL496387 | — | — | 1 | 5.38 |
| CHEMBL510171 | — | — | 1 | 5.34 |
| CHEMBL523563 | — | — | 1 | 5.33 |
| CHEMBL498251 | — | — | 1 | 5.28 |
| CHEMBL497419 | — | — | 1 | 5.25 |
| CHEMBL525001 | — | — | 1 | 5.25 |
| CHEMBL521889 | — | — | 1 | 5.24 |
| CHEMBL496035 | — | — | 1 | 5.19 |
| CHEMBL496227 | — | — | 1 | 5.07 |
| CHEMBL495787 | — | — | 1 | 5.00 |
| CHEMBL497418 | — | — | 1 | 4.89 |
| CHEMBL497011 | LINAPRAZAN | 2.0 | 1 | 4.85 |
| CHEMBL496400 | — | — | 1 | 4.85 |
| CHEMBL498252 | — | — | 1 | 4.85 |
| CHEMBL495786 | — | — | 1 | 4.77 |
| CHEMBL496605 | — | — | 1 | 4.77 |
| CHEMBL496386 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL447822 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL453246 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL526841 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL523752 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL496606 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL521724 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL498026 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL496426 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL496624 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL496806 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL238146 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL498220 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL498114 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL496387 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL510171 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL523563 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL498251 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL497419 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL525001 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL521889 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL496035 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL496227 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL495787 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL497418 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL498252 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL496400 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL497011 | LINAPRAZAN | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL495786 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL496605 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL496386 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL498434 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL496402 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL498840 | — | IC50 | = | 97000.0 | nM | 4.01 |
| CHEMBL495999 | — | IC50 | - | — | - | |
| CHEMBL496204 | — | IC50 | - | — | - |