Assay Detail
Binding
CHEMBL964690
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]citalopram from human SERT expressed in HEK293 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Carbon-11 labeled indolylpropylamine analog as a new potential PET agent for imaging of the serotonin transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.80 | 9.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL490 | PAROXETINE | 4.0 | 1 | 9.38 |
| CHEMBL43048 | MIDOMAFETAMINE | 3.0 | 1 | 9.14 |
| CHEMBL482903 | — | — | 1 | 8.39 |
| CHEMBL549 | CITALOPRAM | 4.0 | 1 | 8.36 |
| CHEMBL520301 | — | — | 1 | 8.19 |
| CHEMBL503609 | — | — | 1 | 7.94 |
| CHEMBL519819 | — | — | 1 | 6.67 |
| CHEMBL520970 | — | — | 1 | 6.43 |
| CHEMBL483316 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL490 | PAROXETINE | Ki | = | 0.42 | nM | 9.38 |
| CHEMBL43048 | MIDOMAFETAMINE | Ki | = | 0.73 | nM | 9.14 |
| CHEMBL482903 | — | Ki | = | 4.11 | nM | 8.39 |
| CHEMBL549 | CITALOPRAM | Ki | = | 4.38 | nM | 8.36 |
| CHEMBL520301 | — | Ki | = | 6.46 | nM | 8.19 |
| CHEMBL503609 | — | Ki | = | 11.4 | nM | 7.94 |
| CHEMBL519819 | — | Ki | = | 213.0 | nM | 6.67 |
| CHEMBL520970 | — | Ki | = | 374.0 | nM | 6.43 |
| CHEMBL483316 | — | Ki | = | 1910.0 | nM | 5.72 |