Assay Detail
ADMET
CHEMBL965361
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Inhibition of CYP2D6
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Potent and selective small-molecule human urotensin-II antagonists with improved pharmacokinetic profiles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.02 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL527199 | — | — | 1 | 6.80 |
| CHEMBL254356 | — | — | 1 | 6.12 |
| CHEMBL453587 | — | — | 1 | 5.46 |
| CHEMBL488642 | — | — | 1 | 5.23 |
| CHEMBL453067 | — | — | 1 | 5.21 |
| CHEMBL452298 | — | — | 1 | 4.80 |
| CHEMBL453329 | — | — | 1 | 4.77 |
| CHEMBL449192 | — | — | 1 | 4.52 |
| CHEMBL507691 | — | — | 1 | 4.48 |
| CHEMBL499582 | — | — | 1 | 4.48 |
| CHEMBL452808 | — | — | 1 | 4.48 |
| CHEMBL453075 | — | — | 1 | 4.48 |
| CHEMBL453074 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL527199 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL254356 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL453587 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL488642 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL453067 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL452298 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL453329 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL449192 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL507691 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL499582 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL452808 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL453075 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL453074 | — | IC50 | = | 33000.0 | nM | 4.48 |