Assay Detail
ADMET
CHEMBL965362
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Inhibition of CYP3A4
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Potent and selective small-molecule human urotensin-II antagonists with improved pharmacokinetic profiles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.45 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL453329 | — | — | 1 | 6.00 |
| CHEMBL254356 | — | — | 1 | 5.85 |
| CHEMBL452298 | — | — | 1 | 5.68 |
| CHEMBL453587 | — | — | 1 | 5.66 |
| CHEMBL453067 | — | — | 1 | 5.58 |
| CHEMBL527199 | — | — | 1 | 5.48 |
| CHEMBL452808 | — | — | 1 | 5.38 |
| CHEMBL453074 | — | — | 1 | 5.34 |
| CHEMBL488642 | — | — | 1 | 5.31 |
| CHEMBL507691 | — | — | 1 | 5.30 |
| CHEMBL449192 | — | — | 1 | 5.19 |
| CHEMBL499582 | — | — | 1 | 5.05 |
| CHEMBL453075 | — | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL453329 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL254356 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL452298 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL453587 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL453067 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL527199 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL452808 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL453074 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL488642 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL507691 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL449192 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL499582 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL453075 | — | IC50 | = | 9100.0 | nM | 5.04 |