Assay Detail
Binding
CHEMBL965669
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Inhibition of human AChE
11
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.82 | 8.00 |
| IC50 | 1 | 6.46 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL464538 | — | — | 1 | 8.00 |
| CHEMBL501587 | — | — | 1 | 7.55 |
| CHEMBL481 | IRINOTECAN | 4.0 | 1 | 7.30 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 6.46 |
| CHEMBL360055 | GALLAMINE | 4.0 | 1 | 4.43 |
| CHEMBL1190 | DECAMETHONIUM | 4.0 | 1 | - |
| CHEMBL1025 | ISOFLUROPHATE | 4.0 | 1 | - |
| CHEMBL450410 | FENAMIPHOS | — | 1 | - |
| CHEMBL504888 | METHAMIDOPHOS | — | 1 | - |
| CHEMBL483105 | — | — | 1 | - |
| CHEMBL509554 | ISOPROPYL METHYLPHOSPHONOFLUORIDATE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL464538 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL501587 | — | Ki | = | 27.95 | nM | 7.55 |
| CHEMBL481 | IRINOTECAN | Ki | = | 50.5 | nM | 7.30 |
| CHEMBL659 | GALANTAMINE | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL360055 | GALLAMINE | Ki | = | 37000.0 | nM | 4.43 |
| CHEMBL1190 | DECAMETHONIUM | Ki | = | 6000000.0 | nM | - |
| CHEMBL1025 | ISOFLUROPHATE | Ki | = | 1.3 | 10'5/M/min | - |
| CHEMBL450410 | FENAMIPHOS | Ki | = | 0.2 | 10'2/M/min | - |
| CHEMBL504888 | METHAMIDOPHOS | Ki | = | 1.9 | 10'3/M/min | - |
| CHEMBL483105 | — | Ki | = | 1.2 | 10'8/M/min | - |
| CHEMBL509554 | ISOPROPYL METHYLPHOSPHONOFLUORIDATE | Ki | = | 2.7 | 10'7/M/min | - |