Assay Detail
Binding
CHEMBL966884
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Inhibition of serotonin uptake at human SERT expressed in human JAR cells
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | JAR |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
3-(Arylamino)-3-phenylpropan-2-olamines as a new series of dual norepinephrine and serotonin reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.03 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1175 | DULOXETINE | 4.0 | 1 | 8.52 |
| CHEMBL467513 | — | — | 1 | 8.52 |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 8.00 |
| CHEMBL467512 | — | — | 1 | 7.77 |
| CHEMBL466501 | — | — | 1 | 7.66 |
| CHEMBL469151 | — | — | 1 | 7.50 |
| CHEMBL466293 | — | — | 1 | 7.48 |
| CHEMBL466500 | — | — | 1 | 7.39 |
| CHEMBL641 | ATOMOXETINE | 4.0 | 1 | 7.32 |
| CHEMBL467123 | — | — | 1 | 7.26 |
| CHEMBL510855 | — | — | 1 | 7.14 |
| CHEMBL504971 | — | — | 1 | 7.12 |
| CHEMBL467323 | — | — | 1 | 6.95 |
| CHEMBL467324 | — | — | 1 | 6.78 |
| CHEMBL466670 | — | — | 1 | 6.74 |
| CHEMBL504892 | — | — | 1 | 6.71 |
| CHEMBL14370 | REBOXETINE | 4.0 | 1 | 6.62 |
| CHEMBL512435 | — | — | 1 | 6.62 |
| CHEMBL454798 | — | — | 1 | 6.54 |
| CHEMBL509228 | — | — | 1 | 6.38 |
| CHEMBL448897 | — | — | 1 | 6.36 |
| CHEMBL506874 | — | — | 1 | 6.08 |
| CHEMBL445743 | — | — | 1 | 5.68 |
| CHEMBL469150 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1175 | DULOXETINE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL467513 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL41 | FLUOXETINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL467512 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL466501 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL469151 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL466293 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL466500 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL641 | ATOMOXETINE | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL467123 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL510855 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL504971 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL467323 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL467324 | — | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL466670 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL504892 | — | IC50 | = | 196.0 | nM | 6.71 |
| CHEMBL14370 | REBOXETINE | IC50 | = | 242.0 | nM | 6.62 |
| CHEMBL512435 | — | IC50 | = | 237.0 | nM | 6.62 |
| CHEMBL454798 | — | IC50 | = | 286.0 | nM | 6.54 |
| CHEMBL509228 | — | IC50 | = | 416.0 | nM | 6.38 |
| CHEMBL448897 | — | IC50 | = | 439.0 | nM | 6.36 |
| CHEMBL506874 | — | IC50 | = | 836.0 | nM | 6.08 |
| CHEMBL445743 | — | IC50 | = | 2105.0 | nM | 5.68 |
| CHEMBL469150 | — | IC50 | = | 2607.0 | nM | 5.58 |