Assay Detail
Functional
CHEMBL969154
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Cytotoxicity against human A2780 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Ipomoeassins A-E, cytotoxic macrocyclic glycoresins from the leaves of Ipomoea squamosa from the Suriname rainforest.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.23 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1554 | DACTINOMYCIN | 4.0 | 1 | 9.10 |
| CHEMBL502784 | IPOMOEASSIN D | — | 1 | 7.46 |
| CHEMBL454218 | IPOMOEASSIN B | — | 1 | 6.40 |
| CHEMBL506305 | IPOMOEASSIN A | — | 1 | 6.30 |
| CHEMBL505295 | IPOMOEASSIN C | — | 1 | 5.54 |
| CHEMBL443118 | IPOMOEASSIN E | — | 1 | 5.48 |
| CHEMBL525977 | — | — | 1 | 4.80 |
| CHEMBL454231 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1554 | DACTINOMYCIN | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL502784 | IPOMOEASSIN D | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL454218 | IPOMOEASSIN B | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL506305 | IPOMOEASSIN A | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL505295 | IPOMOEASSIN C | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL443118 | IPOMOEASSIN E | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL525977 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL454231 | — | IC50 | = | 19100.0 | nM | 4.72 |