Assay Detail
Functional
CHEMBL969854
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Cytotoxicity against human Jurkat cells by Hoechst test
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and preliminary biological evaluation of acridine compounds as potential agents for a combined targeted chemo-radionuclide therapy approach to melanoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.93 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43 | AMSACRINE | 4.0 | 1 | 7.70 |
| CHEMBL3215785 | — | — | 1 | 6.82 |
| CHEMBL9940 | — | — | 1 | 6.52 |
| CHEMBL3217119 | — | — | 1 | 6.43 |
| CHEMBL3215780 | — | — | 1 | 6.31 |
| CHEMBL3216669 | — | — | 1 | 6.22 |
| CHEMBL3216668 | — | — | 1 | 6.22 |
| CHEMBL456562 | — | — | 1 | 6.07 |
| CHEMBL456779 | — | — | 1 | 6.06 |
| CHEMBL3216900 | — | — | 1 | 6.05 |
| CHEMBL3217118 | — | — | 1 | 5.96 |
| CHEMBL1203975 | — | — | 1 | 5.96 |
| CHEMBL508089 | — | — | 1 | 5.92 |
| CHEMBL3216226 | — | — | 1 | 5.85 |
| CHEMBL1203974 | — | — | 1 | 5.85 |
| CHEMBL456561 | — | — | 1 | 5.58 |
| CHEMBL3216908 | — | — | 1 | 5.47 |
| CHEMBL456547 | — | — | 1 | 5.36 |
| CHEMBL3216227 | — | — | 1 | 5.35 |
| CHEMBL3216037 | — | — | 1 | 5.12 |
| CHEMBL456140 | — | — | 1 | 5.11 |
| CHEMBL3215781 | — | — | 1 | 4.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43 | AMSACRINE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3215785 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL9940 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3217119 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL3215780 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL3216669 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3216668 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL456562 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL456779 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL3216900 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3217118 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1203975 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL508089 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3216226 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1203974 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL456561 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3216908 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL456547 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL3216227 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL3216037 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL456140 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL3215781 | — | IC50 | = | 32300.0 | nM | 4.49 |