Assay Detail
Binding
CHEMBL969911
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Inhibition of caspase like 20S proteasome activity in lymphoblastoid cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
C-terminal constrained phenylalanine as a pharmacophoric unit in peptide-based proteasome inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.64 | 6.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL454820 | — | — | 1 | 6.02 |
| CHEMBL449107 | — | — | 1 | 5.83 |
| CHEMBL503692 | — | — | 1 | 5.76 |
| CHEMBL461005 | — | — | 1 | 5.67 |
| CHEMBL449736 | — | — | 1 | 5.63 |
| CHEMBL508164 | — | — | 1 | 5.60 |
| CHEMBL488029 | — | — | 1 | 5.53 |
| CHEMBL486860 | — | — | 1 | 5.41 |
| CHEMBL207990 | EPOXOMYCIN | — | 1 | 5.34 |
| CHEMBL188918 | — | — | 1 | - |
| CHEMBL64925 | MG-132 | — | 1 | - |
| CHEMBL448088 | — | — | 1 | - |
| CHEMBL447652 | — | — | 1 | - |
| CHEMBL488718 | — | — | 1 | - |
| CHEMBL488905 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL454820 | — | IC50 | = | 952.0 | nM | 6.02 |
| CHEMBL449107 | — | IC50 | = | 1481.0 | nM | 5.83 |
| CHEMBL503692 | — | IC50 | = | 1731.0 | nM | 5.76 |
| CHEMBL461005 | — | IC50 | = | 2142.0 | nM | 5.67 |
| CHEMBL449736 | — | IC50 | = | 2354.0 | nM | 5.63 |
| CHEMBL508164 | — | IC50 | = | 2498.0 | nM | 5.60 |
| CHEMBL488029 | — | IC50 | = | 2958.0 | nM | 5.53 |
| CHEMBL486860 | — | IC50 | = | 3917.0 | nM | 5.41 |
| CHEMBL207990 | EPOXOMYCIN | IC50 | = | 4560.0 | nM | 5.34 |
| CHEMBL188918 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL64925 | MG-132 | IC50 | > | 10000.0 | nM | - |
| CHEMBL448088 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL447652 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL488718 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL488905 | — | IC50 | > | 10000.0 | nM | - |