Assay Detail
Binding
CHEMBL970496
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Inhibition of ovine COX1 by enzyme immunoassay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dinitroglyceryl and diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of aspirin, indomethacin and ibuprofen: synthesis, biological evaluation and nitric oxide release studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.35 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 7.00 |
| CHEMBL25 | ASPIRIN | 4.0 | 1 | 6.52 |
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | 5.54 |
| CHEMBL467905 | — | — | 1 | - |
| CHEMBL466447 | — | — | 1 | - |
| CHEMBL466243 | — | — | 1 | - |
| CHEMBL466861 | — | — | 1 | - |
| CHEMBL466862 | — | — | 1 | - |
| CHEMBL466863 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL25 | ASPIRIN | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL521 | IBUPROFEN | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL467905 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL466447 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL466243 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL466861 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL466862 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL466863 | — | IC50 | > | 100000.0 | nM | - |