Assay Detail
Binding
CHEMBL970754
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Inhibition of rat FAAH expressed in Escherichia coli
89
Total Activities
79
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 53 | 7.61 | 10.30 |
| IC50 | 36 | 6.84 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL477372 | — | — | 2 | 10.30 |
| CHEMBL178398 | — | — | 1 | 9.54 |
| CHEMBL468226 | — | — | 1 | 9.52 |
| CHEMBL469198 | — | — | 2 | 9.47 |
| CHEMBL469241 | — | — | 1 | 9.42 |
| CHEMBL513534 | — | — | 1 | 9.20 |
| CHEMBL468357 | — | — | 1 | 9.10 |
| CHEMBL426967 | — | — | 1 | 9.00 |
| CHEMBL450158 | — | — | 2 | 9.00 |
| CHEMBL467796 | — | — | 1 | 9.00 |
| CHEMBL513358 | — | — | 1 | 9.00 |
| CHEMBL502051 | — | — | 1 | 9.00 |
| CHEMBL469051 | — | — | 2 | 8.96 |
| CHEMBL512104 | — | — | 1 | 8.80 |
| CHEMBL178563 | — | — | 1 | 8.52 |
| CHEMBL467368 | — | — | 2 | 8.52 |
| CHEMBL512965 | — | — | 1 | 8.52 |
| CHEMBL511436 | — | — | 1 | 8.44 |
| CHEMBL448922 | — | — | 1 | 8.40 |
| CHEMBL177577 | — | — | 1 | 8.33 |
| CHEMBL467161 | — | — | 1 | 8.30 |
| CHEMBL468189 | — | — | 2 | 8.15 |
| CHEMBL219880 | — | — | 1 | 8.10 |
| CHEMBL467353 | — | — | 1 | 8.10 |
| CHEMBL467817 | — | — | 1 | 8.10 |
| CHEMBL467141 | — | — | 1 | 8.00 |
| CHEMBL177356 | — | — | 1 | 7.92 |
| CHEMBL461163 | — | — | 2 | 7.85 |
| CHEMBL362705 | — | — | 1 | 7.80 |
| CHEMBL452886 | — | — | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL477372 | — | Ki | = | 0.05 | nM | 10.30 |
| CHEMBL178398 | — | Ki | = | 0.29 | nM | 9.54 |
| CHEMBL468226 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL469198 | — | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL469241 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL513534 | — | Ki | = | 0.63 | nM | 9.20 |
| CHEMBL468357 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL502051 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL426967 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL467796 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL513358 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL450158 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL469051 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL512104 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL178563 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL467368 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL512965 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL469198 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL511436 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL448922 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL177577 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL467161 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL468189 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL469051 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL467353 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL467817 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL219880 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL468189 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL467141 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL467368 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL177356 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL461163 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL362705 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL452886 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL426230 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL219942 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL467364 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL178115 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL220784 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL477372 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL467173 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL466961 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL469268 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL468220 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL174048 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL178071 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL450158 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL468220 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL173992 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL178640 | — | Ki | = | 89.0 | nM | 7.05 |