Compound Detail
CHEMBL513534
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Basic Information
| ChEMBL ID | CHEMBL513534 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BNYJEPWYENNTME-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
414.3
MW (Da)
5.27
ALogP
5
HBA
0
HBD
68.9
PSA (Ų)
0.27
QED
1
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.69
Ki 1 meas. best 9.2
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 CHEMBL3229 | Ki | 9.2 | 9.2 | 0.6 | 1 |
| Diacylglycerol lipase-alpha CHEMBL5545 | IC50 | 5.69 | 5.69 | 2041.7 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 | Ki | = | 0.63 | nM | 9.2 | Inhibition of rat FAAH expressed in Escherichia coli | 18630870 |
| Diacylglycerol lipase-alpha | IC50 | = | 2041.74 | nM | 5.69 | Inhibition of full-length human DAGLalpha expressed in HEK293T cell membranes us... | 26584396 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18630870 | 10.1021/jm800136b | Fatty-acid amide hydrolase 1 | 1 |
| 26584396 | 10.1021/acs.jmedchem.5b01627 | Diacylglycerol lipase-alpha | 1 |
Data from ChEMBL 36 via Core Engine