Assay Detail
Functional
CHEMBL970835
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Vasorelaxant activity in K+-depolarized guinea pig ileum longitudinal smooth muscle assessed as inhibition of calcium-induced contraction
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel and cardioselective diltiazem-like calcium channel blockers via virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.09 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23 | DILTIAZEM | 4.0 | 1 | 6.96 |
| CHEMBL506219 | — | — | 1 | 5.48 |
| CHEMBL864 | CARBINOXAMINE | 4.0 | 1 | 5.03 |
| CHEMBL386435 | — | — | 1 | 4.85 |
| CHEMBL459734 | — | — | 1 | 4.78 |
| CHEMBL491663 | — | — | 1 | 4.74 |
| CHEMBL492668 | — | — | 1 | 4.70 |
| CHEMBL301711 | — | — | 1 | 4.69 |
| CHEMBL275742 | DEXPROPRANOLOL | 2.0 | 1 | 4.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23 | DILTIAZEM | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL506219 | — | IC50 | = | 3280.0 | nM | 5.48 |
| CHEMBL864 | CARBINOXAMINE | IC50 | = | 9340.0 | nM | 5.03 |
| CHEMBL386435 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL459734 | — | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL491663 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL492668 | — | IC50 | = | 20200.0 | nM | 4.70 |
| CHEMBL301711 | — | IC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL275742 | DEXPROPRANOLOL | IC50 | = | 27100.0 | nM | 4.57 |