Assay Detail
Binding
CHEMBL971587
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human adrenal corticoid CYP11B1 expressed in chinese hamster V79 MZh cells
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | V79 MZh |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel aldosterone synthase inhibitors with extended carbocyclic skeleton by a combined ligand-based and structure-based drug design approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 6.08 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL212473 | — | — | 1 | 8.15 |
| CHEMBL9298 | FADROZOLE | 2.0 | 1 | 8.00 |
| CHEMBL213587 | — | — | 1 | 7.92 |
| CHEMBL377766 | — | — | 1 | 7.57 |
| CHEMBL158635 | — | — | 1 | 7.10 |
| CHEMBL516643 | — | — | 1 | 6.82 |
| CHEMBL213588 | — | — | 1 | 6.73 |
| CHEMBL523196 | — | — | 1 | 6.19 |
| CHEMBL494315 | — | — | 1 | 6.13 |
| CHEMBL522860 | — | — | 1 | 6.11 |
| CHEMBL493485 | — | — | 1 | 6.02 |
| CHEMBL362968 | — | — | 1 | 5.80 |
| CHEMBL446775 | — | — | 1 | 5.74 |
| CHEMBL524011 | — | — | 1 | 5.71 |
| CHEMBL493089 | — | — | 1 | 5.61 |
| CHEMBL493082 | — | — | 1 | 5.55 |
| CHEMBL495333 | — | — | 1 | 5.53 |
| CHEMBL494712 | — | — | 1 | 5.45 |
| CHEMBL494713 | — | — | 1 | 5.36 |
| CHEMBL365735 | — | — | 1 | 5.24 |
| CHEMBL492891 | — | — | 1 | 5.02 |
| CHEMBL492892 | — | — | 1 | 4.95 |
| CHEMBL501779 | — | — | 1 | 4.70 |
| CHEMBL494515 | — | — | 1 | 4.62 |
| CHEMBL450201 | — | — | 1 | - |
| CHEMBL209047 | — | — | 1 | - |
| CHEMBL460769 | — | — | 1 | - |
| CHEMBL516647 | — | — | 1 | - |
| CHEMBL461618 | — | — | 1 | - |
| CHEMBL495340 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL212473 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL9298 | FADROZOLE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL213587 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL377766 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL158635 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL516643 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL213588 | — | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL523196 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL494315 | — | IC50 | = | 735.0 | nM | 6.13 |
| CHEMBL522860 | — | IC50 | = | 785.0 | nM | 6.11 |
| CHEMBL493485 | — | IC50 | = | 953.0 | nM | 6.02 |
| CHEMBL362968 | — | IC50 | = | 1577.0 | nM | 5.80 |
| CHEMBL446775 | — | IC50 | = | 1811.0 | nM | 5.74 |
| CHEMBL524011 | — | IC50 | = | 1956.0 | nM | 5.71 |
| CHEMBL493089 | — | IC50 | = | 2452.0 | nM | 5.61 |
| CHEMBL493082 | — | IC50 | = | 2804.0 | nM | 5.55 |
| CHEMBL495333 | — | IC50 | = | 2936.0 | nM | 5.53 |
| CHEMBL494712 | — | IC50 | = | 3559.0 | nM | 5.45 |
| CHEMBL494713 | — | IC50 | = | 4329.0 | nM | 5.36 |
| CHEMBL365735 | — | IC50 | = | 5826.0 | nM | 5.24 |
| CHEMBL492891 | — | IC50 | = | 9639.0 | nM | 5.02 |
| CHEMBL492892 | — | IC50 | = | 11307.0 | nM | 4.95 |
| CHEMBL501779 | — | IC50 | = | 19816.0 | nM | 4.70 |
| CHEMBL494515 | — | IC50 | = | 24003.0 | nM | 4.62 |
| CHEMBL212168 | — | IC50 | - | — | - | |
| CHEMBL492876 | — | IC50 | - | — | - | |
| CHEMBL493081 | — | IC50 | - | — | - | |
| CHEMBL494714 | — | IC50 | - | — | - | |
| CHEMBL495140 | — | IC50 | - | — | - | |
| CHEMBL523884 | — | IC50 | - | — | - | |
| CHEMBL495340 | — | IC50 | - | — | - | |
| CHEMBL461618 | — | IC50 | - | — | - | |
| CHEMBL516647 | — | IC50 | - | — | - | |
| CHEMBL460769 | — | IC50 | - | — | - | |
| CHEMBL209047 | — | IC50 | - | — | - | |
| CHEMBL450201 | — | IC50 | - | — | - |