Assay Detail
ADMET
CHEMBL971595
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant CYP2C9 expressed in baculovirus-infected insect microsomes
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel aldosterone synthase inhibitors with extended carbocyclic skeleton by a combined ligand-based and structure-based drug design approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.85 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494713 | — | — | 1 | 7.19 |
| CHEMBL1109 | SULFAPHENAZOLE | 4.0 | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494713 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL1109 | SULFAPHENAZOLE | IC50 | = | 318.0 | nM | 6.50 |