Assay Detail
Binding
CHEMBL972067
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Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in CHO cells
13
Total Activities
7
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Alkaloids from Eschscholzia californica and their capacity to inhibit binding of [3H]8-Hydroxy-2-(di-N-propylamino)tetralin to 5-HT1A receptors in Vitro.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.23 | 8.12 |
| Activity | 4 | - | - |
| Ki | 2 | 6.15 | 7.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19215 | METERGOLINE | 2.0 | 1 | 8.12 |
| CHEMBL464099 | — | — | 2 | 7.07 |
| CHEMBL481839 | ESCHOLTZINE | — | 2 | 5.22 |
| CHEMBL480663 | CARYACHINE | — | 2 | 5.05 |
| CHEMBL538357 | CALIFORNIDINE | — | 2 | - |
| CHEMBL50 | QUERCETIN | 3.0 | 2 | - |
| CHEMBL486179 | PROTOPINE | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19215 | METERGOLINE | EC50 | = | 7.5 | nM | 8.12 |
| CHEMBL464099 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL464099 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL481839 | ESCHOLTZINE | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL480663 | CARYACHINE | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL481839 | ESCHOLTZINE | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL538357 | CALIFORNIDINE | EC50 | > | 100000.0 | nM | - |
| CHEMBL538357 | CALIFORNIDINE | Activity | - | — | - | |
| CHEMBL50 | QUERCETIN | EC50 | > | 100000.0 | nM | - |
| CHEMBL50 | QUERCETIN | Activity | - | — | - | |
| CHEMBL486179 | PROTOPINE | EC50 | > | 100000.0 | nM | - |
| CHEMBL486179 | PROTOPINE | Activity | - | — | - | |
| CHEMBL480663 | CARYACHINE | Activity | = | 5.0 | uM | - |