Assay Detail
Functional
CHEMBL972282
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Myorelaxant activity in potassium depolarized Wistar rat aorta rings assessed as relaxation of KCl-induced contraction
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New R/S-3,4-dihydro-2,2-dimethyl-6-halo-4-(phenylaminothiocarbonylamino)-2H-1-benzopyrans structurally related to (+/-)-cromakalim as tissue-selective pancreatic beta-cell K(ATP) channel openers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 34 | 5.16 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49035 | CROMAKALIM | 2.0 | 1 | 6.89 |
| CHEMBL1159 | PINACIDIL ANHYDROUS | 4.0 | 1 | 6.46 |
| CHEMBL468836 | — | — | 1 | 5.54 |
| CHEMBL502421 | — | — | 1 | 5.50 |
| CHEMBL468387 | — | — | 1 | 5.26 |
| CHEMBL468835 | — | — | 1 | 5.21 |
| CHEMBL496089 | — | — | 1 | 5.19 |
| CHEMBL468985 | — | — | 1 | 5.14 |
| CHEMBL511582 | — | — | 1 | 5.12 |
| CHEMBL468384 | — | — | 1 | 4.96 |
| CHEMBL468634 | — | — | 1 | 4.96 |
| CHEMBL513528 | — | — | 1 | 4.90 |
| CHEMBL468973 | — | — | 1 | 4.67 |
| CHEMBL181 | DIAZOXIDE | 4.0 | 1 | 4.65 |
| CHEMBL469168 | — | — | 1 | 4.61 |
| CHEMBL112668 | — | — | 1 | 4.44 |
| CHEMBL448599 | — | — | 1 | 4.29 |
| CHEMBL512113 | — | — | 1 | - |
| CHEMBL468635 | — | — | 1 | - |
| CHEMBL467555 | — | — | 1 | - |
| CHEMBL467556 | — | — | 1 | - |
| CHEMBL512264 | — | — | 1 | - |
| CHEMBL468422 | — | — | 1 | - |
| CHEMBL468570 | — | — | 1 | - |
| CHEMBL513524 | — | — | 1 | - |
| CHEMBL467766 | — | — | 1 | - |
| CHEMBL501304 | — | — | 1 | - |
| CHEMBL451698 | — | — | 1 | - |
| CHEMBL526087 | — | — | 1 | - |
| CHEMBL497954 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49035 | CROMAKALIM | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1159 | PINACIDIL ANHYDROUS | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL468836 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL502421 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL468387 | — | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL468835 | — | EC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL496089 | — | EC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL468985 | — | EC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL511582 | — | EC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL468384 | — | EC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL468634 | — | EC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL513528 | — | EC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL468973 | — | EC50 | = | 21600.0 | nM | 4.67 |
| CHEMBL181 | DIAZOXIDE | EC50 | = | 22400.0 | nM | 4.65 |
| CHEMBL469168 | — | EC50 | = | 24400.0 | nM | 4.61 |
| CHEMBL112668 | — | EC50 | = | 36300.0 | nM | 4.44 |
| CHEMBL448599 | — | EC50 | = | 51500.0 | nM | 4.29 |
| CHEMBL468986 | — | EC50 | = | 137300.0 | nM | - |
| CHEMBL447283 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL497956 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL497955 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL497954 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL526087 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL451698 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL501304 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL467766 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL513524 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL468570 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL468422 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL512264 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL467556 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL467555 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL468635 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL512113 | — | EC50 | > | 30000.0 | nM | - |