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Assay Detail

CHEMBL972584

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Binding
Inhibition of Aurora B by radiometric assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Aurora kinase B (CHEMBL2185)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of a potent and selective aurora kinase inhibitor.
Oslob JD, Romanowski MJ, Allen DA, Baskaran S, Bui M, Elling RA, Flanagan WM, Fung AD, Hanan EJ, Harris S, Heumann SA, Hoch U, Jacobs JW, Lam J, Lawrence CE, McDowell RS, Nannini MA, Shen W, Silverman JA, Sopko MM, Tangonan BT, Teague J, Yoburn JC, Yu CH, Zhong M, Zimmerman KM, O'Brien T, Lew W.
Bioorg Med Chem Lett (2008) 18 : 4880 -4884
PubMed 18678489 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 7.28 7.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL505037 1 7.89
CHEMBL472193 1 7.85
CHEMBL512184 1 7.75
CHEMBL486877 1 7.72
CHEMBL486850 1 7.66
CHEMBL518051 SNS-314 MESYLATE 1 7.51
CHEMBL520053 1 7.29
CHEMBL513078 1 7.27
CHEMBL487892 1 7.21
CHEMBL472202 1 6.92
CHEMBL519728 1 6.92
CHEMBL471511 1 6.36
CHEMBL471169 1 6.24
CHEMBL472203 1 -
CHEMBL470119 1 -
CHEMBL471337 1 -
CHEMBL472377 1 -
CHEMBL472546 1 -
CHEMBL472194 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL505037 IC50 = 13.0 nM 7.89
CHEMBL472193 IC50 = 14.0 nM 7.85
CHEMBL512184 IC50 = 18.0 nM 7.75
CHEMBL486877 IC50 = 19.0 nM 7.72
CHEMBL486850 IC50 = 22.0 nM 7.66
CHEMBL518051 SNS-314 MESYLATE IC50 = 31.0 nM 7.51
CHEMBL520053 IC50 = 51.0 nM 7.29
CHEMBL513078 IC50 = 54.0 nM 7.27
CHEMBL487892 IC50 = 61.0 nM 7.21
CHEMBL472202 IC50 = 120.0 nM 6.92
CHEMBL519728 IC50 = 120.0 nM 6.92
CHEMBL471511 IC50 = 442.0 nM 6.36
CHEMBL471169 IC50 = 580.0 nM 6.24
CHEMBL472203 IC50 - -
CHEMBL470119 IC50 - -
CHEMBL471337 IC50 - -
CHEMBL472377 IC50 - -
CHEMBL472546 IC50 - -
CHEMBL472194 IC50 - -