Compound Detail
CHEMBL505037
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Basic Information
| ChEMBL ID | CHEMBL505037 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GAROAAIHALTJIR-UHFFFAOYSA-N |
3
Targets
5
Activities
2
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
465.4
MW (Da)
5.75
ALogP
7
HBA
3
HBD
91.8
PSA (Ų)
0.34
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 7.8
IC50 2 meas. best 7.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Aurora kinase B CHEMBL2185 | IC50 | 7.89 | 7.89 | 13.0 | 1 |
| HCT-116 CHEMBL394 | EC50 | 7.8 | 7.74 | 16.0 | 3 |
| Aurora kinase A CHEMBL4722 | IC50 | 7.02 | 7.02 | 96.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Aurora kinase B | IC50 | = | 13.0 | nM | 7.89 | Inhibition of Aurora B by radiometric assay | 18678489 |
| HCT-116 | EC50 | = | 16.0 | nM | 7.8 | Cell cycle arrest in human HCT116 cells assessed as accumulation of 4N DNA phase... | 18678489 |
| HCT-116 | EC50 | = | 16.0 | nM | 7.8 | Decrease in histone H3 phosphorylation in human HCT116 cells after 16 hrs by Wes... | 18678489 |
| HCT-116 | EC50 | = | 24.0 | nM | 7.62 | Antiproliferative activity against human HCT116 cells assessed as BrdU incorpora... | 18678489 |
| Aurora kinase A | IC50 | = | 96.0 | nM | 7.02 | Inhibition of Aurora A by radiometric assay | 18678489 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18678489 | 10.1016/j.bmcl.2008.07.073 | ADMET | 4 |
| 18678489 | 10.1016/j.bmcl.2008.07.073 | Mus musculus | 4 |
| 18678489 | 10.1016/j.bmcl.2008.07.073 | HCT-116 | 3 |
| 18678489 | 10.1016/j.bmcl.2008.07.073 | Aurora kinase A | 1 |
| 18678489 | 10.1016/j.bmcl.2008.07.073 | Aurora kinase B | 1 |
Data from ChEMBL 36 via Core Engine