Assay Detail
Functional
CHEMBL972587
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Decrease in histone H3 phosphorylation in human HCT116 cells after 16 hrs by Western blot
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a potent and selective aurora kinase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.65 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL486850 | — | — | 1 | 7.80 |
| CHEMBL486877 | — | — | 1 | 7.80 |
| CHEMBL505037 | — | — | 1 | 7.80 |
| CHEMBL519728 | — | — | 1 | 7.20 |
| CHEMBL472193 | — | — | 1 | - |
| CHEMBL520053 | — | — | 1 | - |
| CHEMBL518051 | SNS-314 MESYLATE | — | 1 | - |
| CHEMBL512184 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL486850 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL486877 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL505037 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL519728 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL472193 | — | EC50 | < | 16.0 | nM | - |
| CHEMBL520053 | — | EC50 | < | 16.0 | nM | - |
| CHEMBL518051 | SNS-314 MESYLATE | EC50 | < | 16.0 | nM | - |
| CHEMBL512184 | — | EC50 | < | 16.0 | nM | - |