Assay Detail
ADMET
CHEMBL972656
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Inhibition of CYP2D6 in human liver microsomes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.05 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL230744 | — | — | 1 | 6.52 |
| CHEMBL472913 | — | — | 1 | 6.16 |
| CHEMBL472914 | — | — | 1 | 6.11 |
| CHEMBL230743 | — | — | 1 | 5.41 |
| CHEMBL509746 | — | — | 1 | - |
| CHEMBL516051 | — | — | 1 | - |
| CHEMBL490672 | FILIBUVIR | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL230744 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL472913 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL472914 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL230743 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL509746 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL516051 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL490672 | FILIBUVIR | IC50 | > | 30000.0 | nM | - |