Assay Detail
Binding
CHEMBL973055
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of benzofuranic derivatives as new ligands at the melatonin-binding site MT3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.52 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45 | MELATONIN | 4.0 | 1 | 9.70 |
| CHEMBL323332 | — | — | 1 | 9.22 |
| CHEMBL504585 | — | — | 1 | 7.00 |
| CHEMBL505744 | — | — | 1 | 6.72 |
| CHEMBL522674 | — | — | 1 | 5.91 |
| CHEMBL493424 | — | — | 1 | 5.57 |
| CHEMBL494566 | — | — | 1 | 5.41 |
| CHEMBL521826 | — | — | 1 | 5.27 |
| CHEMBL493414 | — | — | 1 | 5.27 |
| CHEMBL495232 | — | — | 1 | 5.09 |
| CHEMBL446329 | — | — | 1 | - |
| CHEMBL493579 | — | — | 1 | - |
| CHEMBL521827 | — | — | 1 | - |
| CHEMBL505118 | — | — | 1 | - |
| CHEMBL522528 | — | — | 1 | - |
| CHEMBL494567 | — | — | 1 | - |
| CHEMBL495241 | — | — | 1 | - |
| CHEMBL495399 | — | — | 1 | - |
| CHEMBL493607 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45 | MELATONIN | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL323332 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL504585 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL505744 | — | IC50 | = | 189.0 | nM | 6.72 |
| CHEMBL522674 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL493424 | — | IC50 | = | 2690.0 | nM | 5.57 |
| CHEMBL494566 | — | IC50 | = | 3880.0 | nM | 5.41 |
| CHEMBL521826 | — | IC50 | = | 5350.0 | nM | 5.27 |
| CHEMBL493414 | — | IC50 | = | 5320.0 | nM | 5.27 |
| CHEMBL495232 | — | IC50 | = | 8180.0 | nM | 5.09 |
| CHEMBL446329 | — | IC50 | - | — | - | |
| CHEMBL493579 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL521827 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL505118 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL522528 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL494567 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL495241 | — | IC50 | - | — | - | |
| CHEMBL495399 | — | IC50 | - | — | - | |
| CHEMBL493607 | — | IC50 | > | 10000.0 | nM | - |