Assay Detail
Binding
CHEMBL974466
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]RX821002 from alpha2 adrenoceptor in human prefrontal cortex neural membrane
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Prefrontal cortex |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel synthesis and pharmacological evaluation as alpha2-adrenoceptor ligands of O-phenylisouronium salts.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 5.88 | 9.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10332 | — | — | 1 | 9.04 |
| CHEMBL134 | CLONIDINE | 4.0 | 1 | 7.68 |
| CHEMBL10316 | IDAZOXAN | 3.0 | 1 | 7.29 |
| CHEMBL451179 | — | — | 1 | 7.11 |
| CHEMBL453692 | — | — | 1 | 5.40 |
| CHEMBL447688 | — | — | 1 | 5.35 |
| CHEMBL452568 | — | — | 1 | 5.27 |
| CHEMBL500626 | — | — | 1 | 5.10 |
| CHEMBL450475 | — | — | 1 | 5.09 |
| CHEMBL453859 | — | — | 1 | 4.98 |
| CHEMBL453236 | — | — | 1 | 4.94 |
| CHEMBL525985 | — | — | 1 | 4.72 |
| CHEMBL453860 | — | — | 1 | 4.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10332 | — | Ki | = | 0.912 | nM | 9.04 |
| CHEMBL134 | CLONIDINE | Ki | = | 20.89 | nM | 7.68 |
| CHEMBL10316 | IDAZOXAN | Ki | = | 51.29 | nM | 7.29 |
| CHEMBL451179 | — | Ki | = | 77.62 | nM | 7.11 |
| CHEMBL453692 | — | Ki | = | 3981.07 | nM | 5.40 |
| CHEMBL447688 | — | Ki | = | 4466.84 | nM | 5.35 |
| CHEMBL452568 | — | Ki | = | 5370.32 | nM | 5.27 |
| CHEMBL500626 | — | Ki | = | 7943.28 | nM | 5.10 |
| CHEMBL450475 | — | Ki | = | 8128.31 | nM | 5.09 |
| CHEMBL453859 | — | Ki | = | 10471.29 | nM | 4.98 |
| CHEMBL453236 | — | Ki | = | 11481.54 | nM | 4.94 |
| CHEMBL525985 | — | Ki | = | 19054.61 | nM | 4.72 |
| CHEMBL453860 | — | Ki | = | 32359.37 | nM | 4.49 |