Assay Detail
Binding
CHEMBL975013
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]spiperone from rat dopamine D2 receptor in brain striatal membrane
12
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and neuropharmacological evaluation of 2-aryl- and alkylapomorphines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.99 | 8.07 |
| Ki | 6 | 7.29 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL458579 | — | — | 2 | 8.38 |
| CHEMBL458397 | — | — | 2 | 7.93 |
| CHEMBL507567 | — | — | 2 | 7.68 |
| CHEMBL3187985 | APOMORPHINE HYDROCHLORIDE | 4.0 | 2 | 7.32 |
| CHEMBL3216443 | — | — | 2 | 6.62 |
| CHEMBL465696 | — | — | 2 | 5.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL458579 | — | Ki | = | 4.14 | nM | 8.38 |
| CHEMBL458579 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL458397 | — | Ki | = | 11.7 | nM | 7.93 |
| CHEMBL507567 | — | Ki | = | 20.7 | nM | 7.68 |
| CHEMBL458397 | — | IC50 | = | 23.3 | nM | 7.63 |
| CHEMBL507567 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL3187985 | APOMORPHINE HYDROCHLORIDE | Ki | = | 47.7 | nM | 7.32 |
| CHEMBL3187985 | APOMORPHINE HYDROCHLORIDE | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL3216443 | — | Ki | = | 242.0 | nM | 6.62 |
| CHEMBL3216443 | — | IC50 | = | 484.0 | nM | 6.32 |
| CHEMBL465696 | — | Ki | = | 1627.0 | nM | 5.79 |
| CHEMBL465696 | — | IC50 | = | 3259.0 | nM | 5.49 |