Assay Detail
Binding
CHEMBL976147
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]citalopram human SerT receptor expressed in LLCPK cells
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | LLCPK |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
8-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors--part II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 7.90 | 9.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL469589 | — | — | 1 | 9.50 |
| CHEMBL469375 | — | — | 1 | 9.40 |
| CHEMBL469376 | — | — | 1 | 9.30 |
| CHEMBL470217 | — | — | 1 | 9.10 |
| CHEMBL490417 | — | — | 1 | 8.90 |
| CHEMBL513875 | — | — | 1 | 8.70 |
| CHEMBL511815 | — | — | 1 | 8.30 |
| CHEMBL469374 | — | — | 1 | 8.10 |
| CHEMBL469345 | — | — | 1 | 8.00 |
| CHEMBL471047 | — | — | 1 | 7.90 |
| CHEMBL522257 | — | — | 1 | 7.70 |
| CHEMBL472290 | — | — | 1 | 7.70 |
| CHEMBL470849 | — | — | 1 | 7.40 |
| CHEMBL511279 | — | — | 1 | 7.20 |
| CHEMBL512724 | — | — | 1 | 7.00 |
| CHEMBL469568 | — | — | 1 | 6.90 |
| CHEMBL469567 | — | — | 1 | 6.80 |
| CHEMBL472289 | — | — | 1 | 6.80 |
| CHEMBL469995 | — | — | 1 | 6.70 |
| CHEMBL513715 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL469589 | — | Ki | = | 0.3162 | nM | 9.50 |
| CHEMBL469375 | — | Ki | = | 0.3981 | nM | 9.40 |
| CHEMBL469376 | — | Ki | = | 0.5012 | nM | 9.30 |
| CHEMBL470217 | — | Ki | = | 0.7943 | nM | 9.10 |
| CHEMBL490417 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL513875 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL511815 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL469374 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL469345 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL471047 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL522257 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL472290 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL470849 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL511279 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL512724 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL469568 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL469567 | — | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL472289 | — | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL469995 | — | Ki | = | 199.53 | nM | 6.70 |
| CHEMBL513715 | — | Ki | = | 316.23 | nM | 6.50 |