Assay Detail
Binding
CHEMBL977016
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Displacement of [125I]RTI55 from SERT
33
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of 2- and 3-substituted-3-phenylpropyl analogs of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine: role of amino, fluoro, hydroxyl, methoxyl, methyl, methylene, and oxo substituents on affinity for the dopamine and serotonin transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 6.49 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL466936 | — | — | 1 | 7.66 |
| CHEMBL26649 | — | — | 1 | 7.44 |
| CHEMBL26477 | — | — | 1 | 7.07 |
| CHEMBL468207 | — | — | 1 | 7.06 |
| CHEMBL466145 | — | — | 1 | 7.06 |
| CHEMBL468208 | — | — | 1 | 6.96 |
| CHEMBL511718 | — | — | 2 | 6.92 |
| CHEMBL281594 | VANOXERINE | 3.0 | 1 | 6.89 |
| CHEMBL26478 | — | — | 1 | 6.87 |
| CHEMBL512636 | — | — | 1 | 6.82 |
| CHEMBL27490 | — | — | 1 | 6.80 |
| CHEMBL513859 | — | — | 1 | 6.72 |
| CHEMBL467585 | — | — | 1 | 6.72 |
| CHEMBL283662 | — | — | 1 | 6.66 |
| CHEMBL513858 | — | — | 1 | 6.66 |
| CHEMBL27646 | — | — | 1 | 6.64 |
| CHEMBL511950 | — | — | 1 | 6.60 |
| CHEMBL468573 | — | — | 1 | 6.60 |
| CHEMBL468211 | — | — | 1 | 6.54 |
| CHEMBL468376 | — | — | 1 | 6.51 |
| CHEMBL466538 | — | — | 1 | 6.37 |
| CHEMBL468212 | — | — | 1 | 6.27 |
| CHEMBL26320 | — | — | 1 | 6.21 |
| CHEMBL27907 | — | — | 1 | 5.89 |
| CHEMBL511756 | — | — | 1 | 5.85 |
| CHEMBL467757 | — | — | 1 | 5.75 |
| CHEMBL282380 | — | — | 1 | 5.75 |
| CHEMBL469165 | — | — | 1 | 5.75 |
| CHEMBL512280 | — | — | 1 | 5.70 |
| CHEMBL28149 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL466936 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL26649 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL26477 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL466145 | — | Ki | = | 88.0 | nM | 7.06 |
| CHEMBL468207 | — | Ki | = | 88.0 | nM | 7.06 |
| CHEMBL468208 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL511718 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL281594 | VANOXERINE | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL26478 | — | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL512636 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL27490 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL467585 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL511718 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL513859 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL283662 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL513858 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL27646 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL511950 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL468573 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL468211 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL468376 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL466538 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL468212 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL26320 | — | Ki | = | 620.0 | nM | 6.21 |
| CHEMBL27907 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL511756 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL467757 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL282380 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL469165 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL512280 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL28149 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL466750 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL466733 | — | Ki | = | 3300.0 | nM | 5.48 |