Assay Detail

CHEMBL977068

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Cell viability of human cisplatin-sensitive human A2780 cells after 24 hrs by MTT assay

ChEMBL ↗

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Target

A2780 (CHEMBL614004) ↗

Open DB target context

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A2780 (CHEMBL614004) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target A2780

CHEMBL614004

Anchored from Assay target.

Protein identity A2780

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	A2780
Confidence	1 — Organism
Curated By	Autocuration

Target

A2780 (CHEMBL614004) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

EF24 induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by increasing PTEN expression.

Selvendiran K, Tong L, Vishwanath S, Bratasz A, Trigg NJ, Kutala VK, Hideg K, Kuppusamy P.
J Biol Chem (2007) 282 : 28609 -28618
PubMed 17684018 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.30	6.30

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL379849	—	—	1	6.30

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL379849	—	IC50	=	500.0	nM	6.30