Assay Detail
Functional
CHEMBL978067
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Cytotoxicity against human RT112 cells after 96 hrs by microtiter assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RT-112 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationships of novel heteroaryl-acrylonitriles as cytotoxic and antibacterial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.52 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL486866 | — | — | 1 | 6.92 |
| CHEMBL440896 | — | — | 1 | 6.36 |
| CHEMBL452338 | — | — | 1 | 6.21 |
| CHEMBL510628 | — | — | 1 | 6.12 |
| CHEMBL509447 | — | — | 1 | 5.96 |
| CHEMBL503790 | — | — | 1 | 5.85 |
| CHEMBL454676 | — | — | 1 | 5.75 |
| CHEMBL508642 | — | — | 1 | 5.66 |
| CHEMBL671 | THIOTEPA | 4.0 | 1 | 5.47 |
| CHEMBL452328 | — | — | 1 | 5.46 |
| CHEMBL507487 | — | — | 1 | 5.41 |
| CHEMBL454418 | — | — | 1 | 5.41 |
| CHEMBL451824 | — | — | 1 | 5.38 |
| CHEMBL447255 | — | — | 1 | 5.33 |
| CHEMBL852 | MELPHALAN | 4.0 | 1 | 5.33 |
| CHEMBL505911 | — | — | 1 | 5.09 |
| CHEMBL455399 | — | — | 1 | 5.09 |
| CHEMBL486867 | — | — | 1 | 4.88 |
| CHEMBL454419 | — | — | 1 | 4.86 |
| CHEMBL519890 | — | — | 1 | 4.83 |
| CHEMBL452337 | — | — | 1 | 4.51 |
| CHEMBL572 | NITROFURANTOIN | 4.0 | 1 | - |
| CHEMBL509840 | — | — | 1 | - |
| CHEMBL455419 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL486866 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL440896 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL452338 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL510628 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL509447 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL503790 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL454676 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL508642 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL671 | THIOTEPA | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL452328 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL507487 | — | IC50 | = | 3880.0 | nM | 5.41 |
| CHEMBL454418 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL451824 | — | IC50 | = | 4160.0 | nM | 5.38 |
| CHEMBL447255 | — | IC50 | = | 4730.0 | nM | 5.33 |
| CHEMBL852 | MELPHALAN | IC50 | = | 4690.0 | nM | 5.33 |
| CHEMBL505911 | — | IC50 | = | 8180.0 | nM | 5.09 |
| CHEMBL455399 | — | IC50 | = | 8190.0 | nM | 5.09 |
| CHEMBL486867 | — | IC50 | = | 13330.0 | nM | 4.88 |
| CHEMBL454419 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL519890 | — | IC50 | = | 14720.0 | nM | 4.83 |
| CHEMBL452337 | — | IC50 | = | 30700.0 | nM | 4.51 |
| CHEMBL572 | NITROFURANTOIN | IC50 | - | — | - | |
| CHEMBL509840 | — | IC50 | - | — | - | |
| CHEMBL455419 | — | IC50 | > | 40000.0 | nM | - |